CAS: 934660-93-2 | Cobimetinib, NX69635
SKU: NX69635-2MG
Product Identifiers
Catalog # | NX69635 |
CAS Number | 934660-93-2 |
PubChem CID | 16222096 |
Chemical Name | Cobimetinib |
IUPAC Name | [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone |
Synonym | XL 518, GDC 0973 |
InChI | InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1 |
InChIKey | BSMCAPRUBJMWDF-KRWDZBQOSA-N |
SMILES | OC1(CN(C1)C(=O)c2ccc(F)c(F)c2Nc3ccc(I)cc3F)[C@@H]4CCCCN4 |
MDL Number | MFCD22124461 |
Specification
MW | 531.3 |
MF | C21H21F3IN3O2 |
Product Notes | Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. |
Cat Number | BISN0121 |
Manufacturer | Apollo Scientific |
Country of Origin | United Kingdom |