CAS: 934660-93-2 | Cobimetinib, NX69635

SKU: NX69635-2MG
CAS: 934660-93-2 | Cobimetinib, NX69635

CAS: 934660-93-2 | Cobimetinib, NX69635

SKU: NX69635-2MG
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Product Identifiers

Catalog # NX69635
CAS Number 934660-93-2
PubChem CID 16222096
Chemical Name Cobimetinib
IUPAC Name [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
Synonym XL 518, GDC 0973
InChI InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChIKey BSMCAPRUBJMWDF-KRWDZBQOSA-N
SMILES OC1(CN(C1)C(=O)c2ccc(F)c(F)c2Nc3ccc(I)cc3F)[C@@H]4CCCCN4
MDL Number MFCD22124461

Specification

MW 531.3
MF C21H21F3IN3O2
Product Notes Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
Cat Number BISN0121
Manufacturer Apollo Scientific
Country of Origin United Kingdom

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